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GW-501516, also known as Cardarine, is a PPAR agonist that has been shown to have positive effects on muscle building, endurance, increased HDL (good) and decreased LDL (bad) cholesterol, and body recomposition. Cardarine currently has no human studies, but rodent studies have been very encouraging.
When combined with exercise, GW-501516 combined with four weeks of running increased running time by 68%; running distance by 70%; and doubled overall muscular endurance. Along with exercise GW-501516 increased mitochondrial growth by 50%. Additionally, GW-501516 on its own has been found to activate many of the genes that activate when an organism goes for a run or exercises.
Cardarine is not hormonal so it is not suppressive of endogenous testosterone.
20 – 24 hours.
10 – 20mg in an 8-week cycle.
The most controversial reported side effect is increased cancer incidence. The one animal study that showed this, out of many studies on Cardarine, used a dose one hundred times larger than the normal dose for over 10 times as long as the research chemical is typically used. This “side effect” is highly disputed. More in-depth studies have found that Cardarine actually reduces tumor size.
Additionally, PPAR agonists have in general been found to have anti-cancer activity.